Seven Copa Sudamericana fixtures hit the card this week. We've crunched the DraftKings odds to build three sharp parlay combinations with serious upside.
Copa Sudamericana Parlay Picks: April 14–17, 2026
The Copa Sudamericana is back with a stacked mid-week slate, and DraftKings is serving up some juicy lines across seven fixtures. We've broken down each match, flagged the best value spots, and assembled three parlay combinations worth your attention. Let's get into it.
Match-by-Match Breakdown
Sao Paulo vs O'Higgins — Tue Apr 14, 11:00 PM UTC
Best Odds (DraftKings): Sao Paulo -286 | Draw +290 | O'Higgins +1200
Sao Paulo are heavy favorites at home in Morumbi, and rightfully so. O'Higgins making the trip from Chile face a massive ask against a Brazilian giant on their own turf. The -286 moneyline reflects that reality, but for parlay purposes Sao Paulo is a rock-solid anchor leg. O'Higgins at +1200 is a pure lottery ticket — avoid unless you're feeling reckless.
Grêmio vs Deportivo Pereira — Tue Apr 14, 11:00 PM UTC
Best Odds (DraftKings): Grêmio -208 | Draw +240 | Deportivo Pereira +850
Grêmio at home is another strong parlay anchor. The -208 price is reasonable for a Brazilian Serie A side hosting Colombian opposition at the Arena do Grêmio. The draw at +240 carries genuine implied value if you believe the visitors can stay compact — but for parlays, Grêmio to win is the call. Pereira at +850 looks like a significant overestimate of their chances on the road.
Vasco da Gama vs Audax Italiano — Wed Apr 15, 1:00 AM UTC
Best Odds (DraftKings): Vasco -250 | Draw +370 | Audax Italiano +550
Vasco are favored, but that draw price at +370 catches the eye. Audax Italiano at +550 is also noteworthy — that implies roughly an 15.4% win probability, which may be a touch generous for a Chilean side visiting Rio. Value Flag: Audax +550 could be worth a small standalone sprinkle given that implied probability feels slightly undercooked for a competitive South American side capable of a point or all three on the road.
Santos vs Recoleta FC — Wed Apr 15, 1:30 AM UTC
Best Odds (DraftKings): Santos -333 | Draw +320 | Recoleta +1300
Santos are massive favorites at Vila Belmiro. Recoleta at +1300 implies just a 7.1% chance — that's a near-certainty for Santos to at minimum not lose. The -333 price makes Santos expensive as a standalone, but as a parlay leg it provides reliable probability. Recoleta +1300 is one of the longest shots on the board this week.
Olimpia Asunción vs Barracas Central — Thu Apr 16, 1:00 AM UTC
Best Odds (DraftKings): Olimpia -161 | Draw +250 | Barracas Central +450
This is one of the more competitive-looking fixtures on the slate. Olimpia are favored but not dominant at -161, suggesting the market respects Barracas Central's threat. Value Flag: Barracas Central at +450 (implied ~18.2%) looks generous for an Argentine side with Sudamericana pedigree. If you believe in upsets, this is your best value play of the week. The draw at +250 also carries appeal in what could be a tight, tactical affair.
Millonarios vs CA Boston River — Thu Apr 16, 3:00 AM UTC
Best Odds (DraftKings): Millonarios -270 | Draw +340 | Boston River +700
Millonarios are heavy home favorites against Uruguayan side Boston River. The -270 is steep but reflects Millonarios' status as one of Colombia's premier clubs playing on home soil in Bogotá. Boston River at +700 is long, but there's mild value if you consider they aren't a complete minnow. For parlay purposes, Millonarios to win is the dependable pick here.
San Lorenzo vs C.D. Cuenca — Fri Apr 17, 1:30 AM UTC
Best Odds (DraftKings): San Lorenzo -169 | C.D. Cuenca +750
No draw line posted here, which is unusual — keep an eye on whether that updates closer to kickoff. San Lorenzo at -169 is the most approachable favorite price of the week among the home Brazilian and Argentine sides. Cuenca at +750 implies just a 11.8% chance — Value Flag: That could be slightly generous given San Lorenzo's home record in continental competition. A solid standalone or final parlay leg.
⚡ Recommended Parlay Combinations
Parlay #1 — The Safe Hammer (3-Leg)
- Sao Paulo ML (-286) — DraftKings
- Santos ML (-333) — DraftKings
- Millonarios ML (-270) — DraftKings
Combined Odds: Approximately +185 to +210 (exact parlay odds vary by book calculation). Three strong home favorites stacked together. Lower variance, solid payout for the risk profile. Best suited for bettors who want a reliable return without too much drama.
Parlay #2 — The Value Hunter (3-Leg)
- Grêmio ML (-208) — DraftKings
- Olimpia ML (-161) — DraftKings
- San Lorenzo ML (-169) — DraftKings
Combined Odds: Approximately +275 to +310. This combination targets three favorited sides at more digestible prices. Olimpia and San Lorenzo both sit in the -160s range, meaning each leg carries realistic upset risk, but the combined payout offers strong value. This is our top-rated parlay of the slate.
Parlay #3 — The Swing Parlay (2-Leg Upset Special)
- Barracas Central +450 — DraftKings
- Audax Italiano +550 — DraftKings
Combined Odds: Approximately +3025 to +3300. This is a low-stake, high-reward swing. Both sides are road underdogs with prices that imply the market may be slightly underrating their chances. Keep stakes minimal — this is a lottery ticket, not a foundation bet. But if both land? You're having a great Thursday.
Best Standalone Value Bets This Week
- Barracas Central +450 (DraftKings) — Best value underdog of the slate. Implied probability of ~18.2% feels low for an Argentine club in continental competition.
- Olimpia vs Barracas Draw +250 (DraftKings) — In a close matchup, the stalemate is a legitimate outcome worth a look.
- San Lorenzo -169 (DraftKings) — Most accessible favorite price of the week with solid upside for a clean win.
Final Thoughts
This Copa Sudamericana slate leans heavily on Brazilian and Argentine home sides doing what they're expected to do — win at home. The real intrigue lies in the Olimpia vs Barracas Central and Vasco vs Audax Italiano fixtures, where the underdog prices carry genuine value. Parlay #2 is our headline recommendation: three favorites at accessible prices with combined odds that make the risk worthwhile. All odds via DraftKings — shop around before locking in.
Gamble responsibly — set a budget before you bet and never wager more than you can afford to lose.
